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Classification: Blood Pressure
Generic Name: Spironolactone
Typical Brand Names: Aldactone

Spironolactone belongs to a group of medications known as the potassium-sparing diuretics. It acts in the kidney to remove excess water from the blood into the urine. Spironolactone blocks the actions of a hormone called aldosterone, which causes an increase in the removal of salts such as sodium from the blood. This removal of salts causes water to be drawn out of the blood and into the kidneys, where it is then excreted in the urine. Removing water from the blood causes a decrease in the volume of fluid circulating through the blood vessels. This drop in fluid volume decreases the effort required by the heart to pump blood around the body.

There are many conditions which may lead to an accumulation of fluid in the body (oedema). Spironolactone is commonly used in conditions such as heart failure, where the pumping mechanism of the heart is less effective. It is used to relieve the symptoms of heart failure, such as the shortness of breath seen with fluid on the lungs. It is also used to remove excess fluid associated with liver failure, as well as in the treatment of excessive levels of aldosterone (hyperaldosteronism).

Spironolactone does not increase the loss of potassium from the body in the urine, therefore there is less risk of developing low potassium levels in the blood (hypokalaemia). When it is used alone it has a weak effect, therefore it is often used in combination with other diuretics.

Product Name Price
Aldactone 25 mg - 30 Tabs $61.53
Aldactone 100 mg - 30 Tabs $126.16
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Aldactone Directions To Use

Athletes must strictly observe that during the use of Aldactone no additional potassium is taken since this would cause a life-threatening increase in the serum potassium level. Lotassiumsparing diuretics have relatively low diuretic effects so that Aldactone can be called a mild diuretic. It is interesting to note that Aldactone is also an antiandrogen since it reduces the androgen level. Female athletes take advantage of spironolactone characteristic by using it to minimize the virilization symptoms during steroid treatment or the symptoms after treatment. For this purpose spironolactone is normally taken daily for 10 to 14 days, ustially in a dose of 50 mg/day. In men this could cause problems since the relationship of the androgen level to the estrogen level changes in favor of the latter. Thus, common side effects of Aldactone in men include pain in the nipples and breast swelling (gynecomastia).

Aldactone Warnings and Side Effects

Before taking Aldactone, tell your doctor if you have kidney disease; have liver disease; have diabetes mellitus; have high levels of potassium in your blood; or are taking a potassium supplement or an angiotensin-converting-enzyme inhibitor (ACE inhibitor). You may not be able to take Aldactone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Aldactone is in the FDA pregnancy category D. This means that Aldactone is known to harm an unborn baby. Do not take Aldactone if you are pregnant. It is not known whether Aldactone passes into breast milk. Do not take Aldactone without first talking to your doctor if you are breast-feeding a baby.

Stop taking Aldactone and seek emergency medical attention if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); an irregular heartbeat, shortness of breath, fatigue, confusion, weakness, numbness, or tingling (caused by high levels of potassium in your blood); or decreased urination. Other, less serious side effects may be more likely to occur. Continue to take Aldactone and talk to your doctor if you experience unusual headache or dizziness; nausea, diarrhea, or a decrease in appetite; dry mouth; bloating; muscle cramps; or lowering of the voice, excessive hair growth, or enlarged breasts. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Aldactone Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Aldactone Storage

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medicine that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medicine.

Aldactone Overdose

Acute over dosage of Aldactone may be manifested by drowsiness, mental confusion, nausea, vomiting, dizziness, or diarrhea. Seek emergency medical attention.

Aldactone More Information

Aldactone is also used in combination with other medicines to treat precocious puberty or myasthenia gravis. Aldactone also may be used to treat certain female patients with abnormal facial hair. Talk to your doctor about the possible risks of using this medicine for your condition.

Aldactone Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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