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Classification: Women's Health
Generic Name: Raloxifene hydrochloride
Typical Brand Names: Evista

Evista tablets contain the active ingredient raloxifene hydrochloride, which is a type of medicine called a selective oestrogen receptor modulator (SERM).

Oestrogen, the main female sex hormone, has many actions throughout the body. Bone tissue, cholesterol metabolism, breast tissue and uterine tissue are all affected by this hormone. At the menopause, blood levels of oestrogen start to decrease and this affects the tissues that are normally responsive to oestrogen.

In terms of bone tissue, declining levels of oestrogen result in an increase in bone breakdown, which can lead to a loss of bone density. Bone loss is particularly rapid for the first ten years after the menopause and it may lead to the development of osteoporosis - a condition in which the bones are weak and break more easily.

Raloxifene is used to both prevent and treat osteoporosis in postmenopausal women. It works by acting on oestrogen receptors in the bone tissue, where it mimicks the natural effects of oestrogen. This gradually reverses the excessive breakdown of bone that happens at menopause and causes an increase in bone mineral density, making bones stronger. Raloxifene has been shown to significantly reduce the risk of spinal fractures, but not hip fractures.

Raloxifene selectively mimicks the effects of oestrogen on bone tissue, but does not affect breast tissue or uterine tissue. This means that long-term use does not carry the increased risk of cancer of the lining of the womb (endometrial cancer) or breast cancer that is associated with long-term use of oestrogen-based hormone replacement therapy (HRT). However, raloxifene is associated with an increased risk of developing blood clots in the veins (venous thromboembolism). This risk is similar to that associated with hormone replacement therapy (HRT).

Product Name Price
Evista 60 mg - 30 Tabs $148.00
Evista 60 mg - 60 Tabs $295.00
Evista 60 mg - 90 Tabs $442.00
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Evista Directions To Use

How much Evista you take and how often you take it depends on many factors, including the condition being treated and the age and weight of the patient. If you have any questions about the amount and/or frequency of the medicine you are taking, talk with your health care provider. Evista may be taken any time of the day with or without food. Stop taking Evista 72 hours before and during prolonged immobilization such as postsurgical recovery and prolonged bed rest. Avoid prolonged restriction of movement during travel because of increased blood-clotting risk. Evista does not reduce hot flashes or flushes associated with estrogen deficiency. Hot flashes may occur upon beginning therapy. Take additional calcium and vitamin D if daily dietary intake is inadequate.

Consider weight-bearing exercise and reduction of cigarette smoking and alcohol consumption. this evista should not be taken if you have not gone through menopause. Evista may cause an increased risk of blood clots, especially during the first 4 months of treatment. Read the package insert before beginning this medicine and re-read upon prescription renewal. Do not stop or change the amount of medicine you are taking unless advised to do so by your health care provider. Patients with other medical conditions should talk with their health care provider before taking this evista. Do not take any other over-the-counter or prescription medications or dietary supplements without talking with your doctor.

Evista Warnings and Side Effects

Before taking this medication, tell your doctor if you have a history of blood clots; stroke; cancer; increased triglycerides (a type of fat in the blood); or liver disease. You may not be able to take Evista, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Evista is in the FDA pregnancy category X. This means that Evista is known to cause birth defects in an unborn baby. Do not take Evista if you are pregnant or if you could become pregnant during treatment. It is not known whether Evista passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Side effects are possible though uncommon. Tell your health care provider if any of the following occurs: Common: Hot flashes; leg cramps; infection; flu syndrome; chest pain; fever;migraine; nausea; indigestion; vomiting; gas; gastrointestinal disorders;stomach ache; weight gain; swelling of the hands or feet; joint pain; muscle pain; depression; sleeplessness; sinus inflammation; sore throat; increased cough; laryngitis; rash; sweating; vaginal inflammation; urinary tract infection;bladder inflammation; vaginal discharge; breast pain; vaginal bleeding.

Evista Missed Dose

If an Evista dose is missed, take or give it as soon as possible. If several hours have passed or if it is nearing time for the next Evista dose, do not double the Evista dose to catch up, unless advised by your doctor. If more than one Evista dose is missed, restart Evista® and advise your doctor or pharmacist at your next visit.

Evista Storage

Store at controlled room temperature, 20o to 25oC (68o to 77oF); allows excursions between 15o and 30oC (59o and 86oF).

Evista Overdose

Incidents of overdose in humans have not been reported. There is no specific antidote for Evista.

Evista More Information

Before having any surgery, tell your doctor that you are taking Evista. Treatment with Evista may need to be stopped temporarily if you require an extended period of bed rest. Avoid sitting still for long periods of time during travel while taking Evista. Alcohol and cigarette smoking may cause increased bone loss. Discuss with your doctor the use of these products.

Evista Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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